Multi-drug interaction intelligence that goes beyond simple alerts.
Orisan Sage
Orisan Sage is a mechanistic drug interaction API and clinical decision support tool. It analyzes the full active medication list using pharmacokinetic and pharmacodynamic principles — not just pairwise database lookups — to surface emergent multi-drug risks that traditional checkers miss entirely.
Problems we solve
Alert Fatigue from Low-Specificity Warnings
Clinicians override 49-96% of drug interaction alerts because most are clinically irrelevant. The real risks get lost in the noise.
Pairwise Checkers Miss Emergent Risks
When Drug A raises Drug B levels and Drug C extends QT interval, the combined risk is invisible to systems that only check pairs.
No Context for Clinical Decisions
A red flag with no mechanism, no magnitude estimate, and no monitoring guidance does not help a prescriber make a better decision.
Polypharmacy Is the Norm, Not the Exception
42% of Americans over 65 take 5+ medications. A checker designed for simple drug pairs cannot serve this population safely.
What you get
Mechanistic Analysis
Models interactions through metabolic pathways, enzyme inhibition/induction, and pharmacodynamic cascades — not just documented drug pairs.
Multi-Drug, Not Pairwise
Analyzes the entire active medication list simultaneously. Surfaces emergent risks from 3, 5, or 15 concurrent medications.
API-First Architecture
REST API that integrates into any clinical workflow — prescribing interfaces, discharge reconciliation, care coordination platforms.
Actionable Clinical Context
Returns the pathway involved, expected magnitude, what to monitor, and at what threshold to act — not just a severity color code.
Evidence-Based Alerts
Reduces alert fatigue by increasing specificity. Clinicians see fewer, more relevant warnings they can actually act on.
Per-Transaction Pricing
Pay for what you use. No enterprise seat licenses, no annual minimums for small practices.
Integrations & Standards
See Orisan Sage in action
Schedule a conversation with our team to learn how Orisan Sage can help your practice.
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